European Immunology

Inflammation Biology & Chronic Immune Disorders

Chronic inflammation is a driver of numerous diseases including arthritis, cardiovascular disorders, neurodegeneration and metabolic syndromes. Research continues to identify the cellular and molecular triggers that sustain inflammatory cycles, including cytokine cascades, dysregulated innate sensors, unresolved tissue damage and metabolic dysfunction. Innovative therapies target inflammatory mediators, intracellular signaling pathways and specific immune cell subsets to restore balance without broad suppression. Anti-inflammatory biologics, small-molecule inhibitors, epigenetic modulators and metabolic regulators are expanding treatment possibilities. Understanding the interplay between chronic inflammation and aging, microbiome composition and comorbidities enables more effective long-term management strategies and precision-based interventions.