European Immunology

Immunometabolism & Cellular Energy Dynamics

Immunometabolism explores how metabolic pathways govern immune cell activation, differentiation and function. T cells, macrophages, dendritic cells and NK cells rely on distinct metabolic programs that shape their ability to fight infection, eliminate tumors or maintain tolerance. Disruptions in metabolic signaling contribute to inflammatory diseases, cancer progression and immunotherapy resistance. Cutting-edge research focuses on manipulating glycolysis, oxidative phosphorylation, amino acid metabolism and lipid pathways to modulate immune responses with precision. Metabolic inhibitors, nutrient-sensing pathway modulators and engineered enzymes are emerging as powerful tools for immune control. Systems biology and metabolomics are helping map the metabolic states associated with diverse immune conditions. Therapies targeting metabolic checkpoints offer new opportunities to enhance CAR-T cell persistence, reduce autoimmune flares and influence macrophage polarization. Immunometabolism has become a critical frontier that links cellular energetics with immune outcomes, offering transformative therapeutic potential.