European Immunology

Allergy, Hypersensitivity & Immune Tolerance Strategies

Allergic diseases are driven by inappropriate immune reactions to harmless substances, mediated through IgE responses, mast cell activation and dysregulated T-cell polarization. Innovative research focuses on the molecular pathways underlying hypersensitivity and how immune tolerance can be reestablished. Approaches include allergen-specific immunotherapy, recombinant allergen design, Treg-inducing vaccines, microbiome modulation and targeted blockade of inflammatory mediators such as IL-4, IL-5 and IL-13. Advances in diagnostic biomarkers and precision phenotyping enable more individualized treatment strategies. Understanding genetic predisposition, environmental exposures and epithelial barrier defects helps refine preventive measures. The future of allergy treatment lies in targeted and durable immune tolerance induction, moving beyond symptom control toward long-term correction of immune dysfunction.