European Immunology

Immunodeficiency

Immunodeficiency disorders impair the immune system's ability to defend against infections and diseases, resulting from genetic defects (primary immunodeficiencies) or acquired conditions (secondary immunodeficiencies). Primary immunodeficiencies affect immune cell development, function, or signaling pathways, leading to recurrent infections, opportunistic infections, and increased susceptibility to autoimmune diseases or cancers. Secondary immunodeficiencies can arise from infections, medications (e.g., chemotherapy), malnutrition, or aging, compromising immune responses and overall health. Management includes immunoglobulin replacement therapy, antimicrobial prophylaxis, and stem cell transplantation to restore immune function and improve quality of life for patients with immunodeficiency disorders.