Olena Getsko
The Chinese University of Hong Kong (CUHK), Hong Kong
Title: Does immunological memory stand behind onset of human parturition?
Biography
Biography: Olena Getsko
Abstract
Statement of the problem: The immune system plays a crucial role in establishing and maintaining pregnancy. Adaptation of the maternal immune response is essential for good pregnancy outcomes. Conversely, insufficient immune adaption is associated with pregnancy pathologies such as recurrent miscarriage, fetal growth restriction, preterm birth, and preeclampsia. Memory T cells are responsible for fetal-maternal tolerance. Recent data showed that a delicate balance of memory T cells is necessary for reproductive success. Parturition is the final step of a reproduction cycle. However, the role of memory T cells in human parturition remains unknown. This study aims to investigate differences and changes in CD8+ memory T cells and exhausted molecules expression in groups with spontaneous labor and induction of labor.