Jianqing Xu
Fudan University, China
Title: A single vaccine protects against coronavirus and influenza virus in mice
Biography
Biography: Jianqing Xu
Abstract
The ongoing SARS-CoV-2 pandemic posed a severe global threat of respiratory virus infections on public health, as do so by influenza viruses and other coronaviruses. The currently envisioned strategy for prevention requires comprehensive administration of vaccines tailored for individual virus. Here we present an alternative strategy by designing chimpanzee adenovirus 68 (AdC68)-based multi-immunogen vaccines universally targeting different coronaviruses and influenza viruses. The first version constructed features a fusion immunogen comprising SARS- CoV-2 receptor-binding domain (RBD), conserved stalk of H7N9 hemagglutinin (HA) and human ferritin. Its administration in mice induced neutralizing antibodies against wild-complemented with high- immunogenicity peptide from divergent coronaviruses. The broad spectrum of this improved version was demonstrated by affording protection from SHC014 attack, a bat SARS-like coronaviruses, in mouse model. Also, in order to broaden the influenza virus coverage, we constructed vaccine comprising conserved stalk of H7N9 HA and H1N1 HA. These results together support the promise of our AdC68 vectored pan- coronavirus-influenza virus vaccine and warrant its future exploration as a more effective approach toward curbing respiratory virus-causing pandemics.